![]() Gary Baker, provided very thoughtful insights that assisted me in critically thinking about my research. ![]() The members of my graduate committee, Dr. Truman VA Hospital very memorable and I am truly grateful. Tammy and Ashley made the times I spent over in the Hoffman research labs at the Harry S. Also, special thanks to Ashley Berendzen for her contributions to the mice SPECT/CT imaging studies. I will like to specially acknowledge Tammy Rold for her contributions towards the in vitro cell studies and in vivo mice studies described in this dissertation. I owe the success of the research described in this dissertation to their dedication in nurturing me into a competent scientist by patiently teaching me the skills and expertise needed to be successful in my research. Timothy Hoffman for their incredible support, encouragement, mentorship and guidance throughout my graduate studies. BakerĤ Dedication This dissertation is dedicated to my lovely parents, Sir Josiah Okoye and Lady Charity Okoye, for their selfless sacrifice in ensuring that I got a good education.ĥ Acknowledgments I am very grateful to my advisors, Dr. Okoye, a candidate for the degree of Doctor of Philosophy in Chemistry, and hereby certify that, in their opinion, it is worthy of acceptance. Okoye 2019 All Rights Reservedģ The undersigned, appointed by the dean of the Graduate School at the University of Missouri-Columbia, have examined the dissertation entitled Synthesis and Preclinical Evaluation of Peptide Receptor-targeted Diagnostic and Therapeutic Radiopharmaceuticals for Prostate Cancer presented by Nkemakonam C. Hoffman MAY 2019Ģ Copyright by Nkemakonam C. The risk of neuroendocrine tumors is higher in people who inherit genetic syndromes that increase the risk of cancer.1 SYNTHESIS AND PRECLINICAL EVALUATION OF PEPTIDE RECEPTOR-TARGETED DIAGNOSTIC AND THERAPEUTIC RADIOPHARMACEUTICALS FOR PROSTATE CANCER A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia In partial fulfillment of the requirements for the degree Doctor of Philosophy Submitted by NKEMAKONAM CHUKWUEBUKA OKOYE Under the Supervision of Professor Silvia S. Others are aggressive cancers that invade and destroy normal body tissue or spread (metastasize) to other parts of the body. Some neuroendocrine tumors grow very slowly. The changes tell the neuroendocrine cells to multiply rapidly and form a tumor. The DNA inside a cell contains the instructions that tell the cell what to do. ![]() Neuroendocrine tumors begin when neuroendocrine cells develop changes (mutations) in their DNA. Neuroendocrine cells are found throughout your body. These cancers begin in neuroendocrine cells that have traits similar to those of nerve cells and hormone-producing cells. The exact cause of neuroendocrine tumors isn't known. Make an appointment with your doctor if you have any persistent signs and symptoms that worry you. Neuroendocrine tumors that produce excess hormones (functional tumors) might cause:
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